– моментальные уведомления о рынке акций
– моментальные уведомления о рынке акций
SAN FRANCISCO, May 5, 2022 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today reported financial results for the first quarter ended March 31, 2022.
Cash and investments in marketable securities at March 31, 2022 were approximately $704.4 million as compared to $798.8 million at December 31, 2021, which is expected to support operations into 2025.
"The new strategic plan that we recently announced refocuses our company around specific investment into our most important pipeline programs – NKTR-358, NKTR-255, and core preclinical candidates," said Howard W. Robin, President and CEO of Nektar. "In addition, we have now implemented a cost restructuring plan which extends our cash runway through the first half of 2025. We believe our pipeline in auto-immune disease and oncology provides a path to bringing important therapeutics to patients and creating value for our shareholders."
Revenue in the first quarter of 2022 was $24.8 million as compared to $23.6 million in the first quarter of 2021.
Total operating costs and expenses in the first quarter of 2022 were $141.4 million as compared to $133.0 million in the first quarter of 2021. Operating costs and expenses increased primarily as a result of an increase in R&D expense.
R&D expense in the first quarter of 2022 was $107.3 million as compared to $95.6 million for the first quarter of 2021. R&D expense increased primarily due to increases in expense for bempegaldesleukin, NKTR-255 and NKTR-358.
G&A expense was $27.3 million in the first quarter of 2022 and $31.7 million in the first quarter of 2021.
Net loss for the first quarter of 2022 was $90.4 million or $0.49 basic and diluted loss per share as compared to a net loss of $123.0 million or $0.68 basic and diluted loss per share in the first quarter of 2021.
On April 25, 2022, Nektar announced new strategic and cost restructuring plans (https://ir.nektar.com/news-releases/news-release-details/nektar-therapeutics-announces-strategic-reorganization-plan-and) and conducted a call with analysts and investors to present those plans. On that call, the company provided annual financial guidance for 2022, and because of that, the company stated it would not hold its regular quarterly conference call conducted in conjunction with release of Q1 2022 financial results.
Nektar Therapeutics is a biopharmaceutical company with a robust, wholly owned R&D pipeline of investigational medicines in oncology, immunology, and inflammatory diseases as well as a portfolio of approved partnered medicines. Nektar is headquartered in San Francisco, California, with additional operations in Huntsville, Alabama and Hyderabad, India. Further information about the company and its drug development programs and capabilities may be found online at http://www.nektar.com.
This press release contains forward-looking statements which can be identified by words such as: "will," "may," "extend," "potential," "create," "provide"" and similar references to future periods. Examples of forward-looking statements include, among others, statements we make regarding the therapeutic potential of, and future development plans for NKTR-358, NKTR-255 and our other drug candidates in research programs, the prospects and plans for our collaborations with other companies, the timing of the initiation of clinical studies and the data readouts for our drug candidates, and our expectations (including our expected charges and cost savings) following our corporate restructuring, reorganization and workforce reduction, and our expected working capital and our cash runway. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results to differ materially from those indicated in the forward-looking statements include, among others: (i) our statements regarding the therapeutic potential of NKTR-358,NKTR-255 and our other drug candidates are based on preclinical and clinical findings and observations and are subject to change as research and development continue; (ii) NKTR-358,NKTR-255 and our other drug candidates are investigational agents and continued research and development for these drug candidates is subject to substantial risks, including negative safety and efficacy findings in ongoing clinical studies (notwithstanding positive findings in earlier preclinical and clinical studies); (iii) NKTR-358,NKTR-255 and our other drug candidates are in various stages of clinical development and the risk of failure is high and can unexpectedly occur at any stage prior to regulatory approval; (iv) the timing of the commencement or end of clinical trials and the availability of clinical data may be delayed or unsuccessful due to challenges caused by the COVID-19 pandemic, regulatory delays, slower than anticipated patient enrollment, manufacturing challenges, changing standards of care, evolving regulatory requirements, clinical trial design, clinical outcomes, competitive factors, or delay or failure in ultimately obtaining regulatory approval in one or more important markets; (v) we may not achieve the expected costs savings we expect from the restructuring and reorganization, (vi) patents may not issue from our patent applications for our drug candidates, patents that have issued may not be enforceable, or additional intellectual property licenses from third parties may be required; and (vii) certain other important risks and uncertainties set forth in our Annual Report on Form 10-K filed with the Securities and Exchange Commission on March 1, 2022. Any forward-looking statement made by us in this press release is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.
Vivian Wu of Nektar Therapeutics628-895-0661
NEKTAR THERAPEUTICS |
|||||||||||
CONDENSED CONSOLIDATED BALANCE SHEETS |
|||||||||||
(In thousands) |
|||||||||||
(Unaudited) |
|||||||||||
ASSETS |
March 31, 2022 |
December 31, 2021 |
(1) |
||||||||
Current assets: |
|||||||||||
Cash and cash equivalents |
$ 67,993 |
$ 25,218 |
|||||||||
Short-term investments |
599,032 |
708,737 |
|||||||||
Accounts receivable |
30,220 |
22,492 |
|||||||||
Inventory |
15,379 |
15,801 |
|||||||||
Other current assets |
20,831 |
23,333 |
|||||||||
Total current assets |
733,455 |
795,581 |
|||||||||
Long-term investments |
37,363 |
64,828 |
|||||||||
Property, plant and equipment, net |
60,980 |
60,510 |
|||||||||
Operating lease right-of-use assets |
114,296 |
117,025 |
|||||||||
Goodwill |
76,501 |
76,501 |
|||||||||
Other assets |
1,521 |
2,744 |
|||||||||
Total assets |
$ 1,024,116 |
$ 1,117,189 |
|||||||||
LIABILITIES AND STOCKHOLDERS' EQUITY |
|||||||||||
Current liabilities: |
|||||||||||
Accounts payable |
12,617 |
9,747 |
|||||||||
Accrued compensation |
22,653 |
15,735 |
|||||||||
Accrued clinical trial expenses |
33,403 |
26,809 |
|||||||||
Other accrued expenses |
17,011 |
15,468 |
|||||||||
Operating lease liabilities, current portion |
19,597 |
17,441 |
|||||||||
Total current liabilities |
105,281 |
85,200 |
|||||||||
Operating lease liabilities, less current portion |
122,638 |
125,736 |
|||||||||
Development derivative liability |
- |
27,726 |
|||||||||
Liabilities related to the sales of future royalties, net |
185,604 |
195,427 |
|||||||||
Other long-term liabilities |
2,704 |
3,592 |
|||||||||
Total liabilities |
416,227 |
437,681 |
|||||||||
Commitments and contingencies |
|||||||||||
Stockholders' equity: |
|||||||||||
Preferred stock |
- |
- |
|||||||||
Common stock |
19 |
19 |
|||||||||
Capital in excess of par value |
3,537,790 |
3,516,641 |
|||||||||
Accumulated other comprehensive loss |
(6,532) |
(4,157) |
|||||||||
Accumulated deficit |
(2,923,388) |
(2,832,995) |
|||||||||
Total stockholders' equity |
607,889 |
679,508 |
|||||||||
Total liabilities and stockholders' equity |
$ 1,024,116 |
$ 1,117,189 |
|||||||||
(1) The consolidated balance sheet at December 31, 2021 has been derived from the audited financial statements at that date but does not include all |
|||||||||||
of the information and notes required by generally accepted accounting principles in the United States for complete financial statements. |
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NEKTAR THERAPEUTICS |
|||||||||||
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS |
|||||||||||
(In thousands, except per share information) |
|||||||||||
(Unaudited) |
|||||||||||
Three months ended March 31, |
|||||||||||
2022 |
2021 |
||||||||||
Revenue: |
|||||||||||
Product sales |
$ 5,688 |
$ 4,795 |
|||||||||
Non-cash royalty revenue related to the sales of future royalties |
17,561 |
18,798 |
|||||||||
License, collaboration and other revenue |
1,573 |
54 |
|||||||||
Total revenue |
24,822 |
23,647 |
|||||||||
Operating costs and expenses: |
|||||||||||
Cost of goods sold |
5,315 |
5,756 |
|||||||||
Research and development |
107,253 |
95,604 |
|||||||||
General and administrative |
27,339 |
31,679 |
|||||||||
Restructuring, impairment and other costs of terminated program |
1,475 |
- |
|||||||||
Total operating costs and expenses |
141,382 |
133,039 |
|||||||||
Loss from operations |
(116,560) |
(109,392) |
|||||||||
Non-operating income (expense): |
|||||||||||
Change in fair value of development derivative liability |
33,427 |
(1,599) |
|||||||||
Non-cash interest expense on liabilities related to the sales of future royalties |
(7,529) |
(13,296) |
|||||||||
Interest income and other income (expense), net |
395 |
1,412 |
|||||||||
Total non-operating expense, net |
26,293 |
(13,483) |
|||||||||
Loss before provision for income taxes |
(90,267) |
(122,875) |
|||||||||
Provision for income taxes |
126 |
92 |
|||||||||
Net loss |
$ (90,393) |
$ (122,967) |
|||||||||
Basic and diluted net loss per share |
$ (0.49) |
$ (0.68) |
|||||||||
Weighted average shares outstanding used in computing basic and diluted net loss per share |
185,848 |
181,370 |
|||||||||
NEKTAR THERAPEUTICS |
|||||||||||
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS |
|||||||||||
(In thousands) |
|||||||||||
(Unaudited) |
|||||||||||
Three months ended March 31, |
|||||||||||
2022 |
2021 |
||||||||||
Cash flows from operating activities: |
|||||||||||
Net loss |
$ (90,393) |
$ (122,967) |
|||||||||
Adjustments to reconcile net loss to net cash used in operating activities: |
|||||||||||
Non-cash royalty revenue related to the sales of future royalties |
(17,561) |
(18,798) |
|||||||||
Non-cash interest expense on liabilities related to the sales of future royalties |
7,529 |
13,296 |
|||||||||
Change in fair value of development derivative liability |
(33,427) |
1,599 |
|||||||||
Non-cash research and development expense |
4,951 |
2,248 |
|||||||||
Stock-based compensation |
20,961 |
23,898 |
|||||||||
Depreciation and amortization |
3,730 |
3,543 |
|||||||||
Amortization of premiums (discounts), net and other non-cash transactions |
1,276 |
2,345 |
|||||||||
Changes in operating assets and liabilities: |
|||||||||||
Accounts receivable |
(7,728) |
9,733 |
|||||||||
Inventory |
422 |
(1,516) |
|||||||||
Operating leases, net |
1,787 |
1,541 |
|||||||||
Other assets |
2,864 |
6,183 |
|||||||||
Accounts payable |
2,998 |
779 |
|||||||||
Accrued compensation |
6,918 |
8,981 |
|||||||||
Other accrued expenses |
7,249 |
(7,950) |
|||||||||
Net cash used in operating activities |
(88,424) |
(77,085) |
|||||||||
Cash flows from investing activities: |
|||||||||||
Purchases of investments |
(93,493) |
(295,314) |
|||||||||
Maturities of investments |
227,974 |
303,612 |
|||||||||
Sales of investments |
- |
5,036 |
|||||||||
Purchases of property, plant and equipment |
(4,203) |
(2,876) |
|||||||||
Net cash provided by investing activities |
130,278 |
10,458 |
|||||||||
Cash flows from financing activities: |
|||||||||||
Proceeds from shares issued under equity compensation plans |
188 |
17,106 |
|||||||||
Cash receipts from development derivative liability |
750 |
750 |
|||||||||
Net cash provided by financing activities |
938 |
17,856 |
|||||||||
Effect of foreign exchange rates on cash and cash equivalents |
(17) |
(20) |
|||||||||
Net increase (decrease) in cash and cash equivalents |
42,775 |
(48,791) |
|||||||||
Cash and cash equivalents at beginning of period |
25,218 |
198,955 |
|||||||||
Cash and cash equivalents at end of period |
$ 67,993 |
$ 150,164 |
|||||||||
Supplemental disclosure of cash flow information: |
|||||||||||
Operating lease right-of-use asset recognized in exchange for lease liabilities |
$ - |
$ 1,057 |
|||||||||
SOURCE Nektar Therapeutics
САН-ФРАНЦИСКО, 5 мая 2022 г. /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) сегодня сообщила о финансовых результатах за первый квартал, закончившийся 31 марта 2022 года.
Денежные средства и инвестиции в рыночные ценные бумаги на 31 марта 2022 года составили примерно 704,4 млн долларов США по сравнению с 798,8 млн долларов США на 31 декабря 2021 года, что, как ожидается, обеспечит поддержку операций в 2025 году.
"Новый стратегический план, который мы недавно объявили, переориентирует нашу компанию на конкретные инвестиции в наши наиболее важные трубопроводные программы – NKTR-358, NKTR-255 и основные доклинические кандидаты", - сказал Говард У. Робин, президент и главный исполнительный директор Nektar. "Кроме того, в настоящее время мы внедрили план реструктуризации затрат, который продлевает нашу денежную полосу до первой половины 2025 года. Мы считаем, что наш конвейер в области аутоиммунных заболеваний и онкологии открывает путь к предоставлению важных терапевтических препаратов пациентам и созданию ценности для наших акционеров ".
Выручка в первом квартале 2022 года составила 24,8 миллиона долларов по сравнению с 23,6 миллионами долларов в первом квартале 2021 года.
Общие операционные расходы и расходы в первом квартале 2022 года составили 141,4 миллиона долларов по сравнению с 133,0 миллионами долларов в первом квартале 2021 года. Операционные расходы и расходы увеличились в основном в результате увеличения расходов на НИОКР.
Расходы на НИОКР в первом квартале 2022 года составили 107,3 млн долларов по сравнению с 95,6 млн долларов за первый квартал 2021 года. Расходы на НИОКР увеличились в основном из-за увеличения расходов на бемпегальдеслейкин, NKTR-255 и NKTR-358.
Расходы на G&A составили 27,3 миллиона долларов в первом квартале 2022 года и 31,7 миллиона долларов в первом квартале 2021 года.
Чистый убыток за первый квартал 2022 года составил 90,4 млн долларов или 0,49 базового и разводненного убытка на акцию по сравнению с чистым убытком в размере 123,0 млн долларов или 0,68 базового и разводненного убытка на акцию в первом квартале 2021 года.
25 апреля 2022 года Nektar объявила о новых стратегических планах и планах реструктуризации затрат (https://ir.nektar.com/news-releases/news-release-details/nektar-therapeutics-announces-strategic-reorganization-plan-and ) и провел телефонный разговор с аналитиками и инвесторами, чтобы представить эти планы. В ходе этого звонка компания предоставила ежегодные финансовые рекомендации на 2022 год, и из-за этого компания заявила, что не будет проводить свою регулярную ежеквартальную телефонную конференцию, проводимую в связи с публикацией финансовых результатов за 1 квартал 2022 года.
Nektar Therapeutics - это биофармацевтическая компания с надежной, полностью принадлежащей научно-исследовательской цепочкой исследуемых лекарств в области онкологии, иммунологии и воспалительных заболеваний, а также портфелем одобренных партнерских лекарств. Штаб-квартира Nektar находится в Сан-Франциско, штат Калифорния, с дополнительными операциями в Хантсвилле, штат Алабама, и Хайдарабаде, Индия. Дополнительную информацию о компании, ее программах и возможностях по разработке лекарств можно найти в Интернете по адресу http://www.nektar.com .
Этот пресс-релиз содержит заявления прогнозного характера, которые могут быть идентифицированы такими словами, как: "будет", "может", "продлить", "потенциал", "создать", "обеспечить" и аналогичные ссылки на будущие периоды. Примеры прогнозных заявлений включают, среди прочего, заявления, которые мы делаем относительно терапевтического потенциала и будущих планов разработки NKTR-358, NKTR-255 и других наших препаратов-кандидатов в исследовательских программах, перспектив и планов нашего сотрудничества с другими компаниями, сроков начала клинических исследований и данные о наших кандидатах на лекарства, и наши ожидания (включая ожидаемые расходы и экономию средств) после нашей корпоративной реструктуризации, реорганизации и сокращения персонала, а также наш ожидаемый оборотный капитал и наш денежный поток. Прогнозные заявления не являются ни историческими фактами, ни гарантиями будущих результатов. Вместо этого они основаны только на наших текущих убеждениях, ожиданиях и предположениях относительно будущего нашего бизнеса, будущих планов и стратегий, ожидаемых событий и тенденций, экономики и других будущих условий. Поскольку прогнозные заявления относятся к будущему, они подвержены присущим им неопределенностям, рискам и изменениям обстоятельств, которые трудно предсказать и многие из которых находятся вне нашего контроля. Наши фактические результаты могут существенно отличаться от тех, которые указаны в прогнозных заявлениях. Поэтому вам не следует полагаться ни на одно из этих прогнозных заявлений. Важные факторы, которые могут привести к тому, что наши фактические результаты будут существенно отличаться от тех, которые указаны в прогнозных заявлениях, включают, среди прочего: (i) наши заявления относительно терапевтического потенциала NKTR-358, NKTR-255 и других наших препаратов-кандидатов основаны на доклинических и клинических результатах и наблюдениях и подлежат изменения по мере продолжения исследований и разработок; (ii) NKTR-358, NKTR-255 и другие наши лекарственные препараты-кандидаты являются исследуемыми агентами, и продолжение исследований и разработок для этих препаратов-кандидатов сопряжено со значительными рисками, включая отрицательные результаты по безопасности и эффективности в текущих клинических исследованиях (несмотря на положительные результаты предыдущих доклинических и клинических исследований); (iii) NKTR-358, NKTR-255 и другие наши лекарственные препараты-кандидаты находятся на различных стадиях клинической разработки, и риск неудачи высок и может неожиданно возникнуть на любом этапе до утверждения регулирующими органами; (iv) сроки начала или окончания клинических испытаний и доступность клинических данных может быть отложено или не увенчаться успехом из-за проблем, вызванных пандемией COVID-19, задержек с регулированием, более медленного, чем ожидалось, приема пациентов, производственных проблем, изменения стандартов медицинской помощи, меняющихся нормативных требований, дизайна клинических испытаний, клинических результатов, факторов конкуренции или задержки или неудачи в конечном итоге в получении одобрения регулирующих органов в одном или нескольких важные рынки; (v) мы можем не достичь ожидаемой экономии затрат, которую мы ожидаем от реструктуризации и реорганизации, (vi) патенты могут не выдаваться из наших патентных заявок на наши лекарственные препараты-кандидаты, выданные патенты могут не подлежать принудительному исполнению, или могут потребоваться дополнительные лицензии на интеллектуальную собственность от третьих сторон; и (vii) некоторые другие важные риски и неопределенности, изложенные в нашем Годовом отчете по форме 10-K, поданном в Комиссию по ценным бумагам и биржам 1 марта 2022 года. Любое прогнозное заявление, сделанное нами в этом пресс-релизе, основано только на информации, доступной нам в настоящее время, и относится только к дате, на которую оно сделано. Мы не берем на себя никаких обязательств по обновлению любых прогнозных заявлений, будь то письменных или устных, которые могут быть сделаны время от времени, будь то в результате новой информации, будущих событий или иным образом.
Вивиан Ву из Nektar Therapeutics628-895-0661
Nektar Therapeutics |
|||||||||||
CONDENSED CONSOLIDATED BALANCE SHEETS |
|||||||||||
(In thousands) |
|||||||||||
(Unaudited) |
|||||||||||
ASSETS |
March 31, 2022 |
December 31, 2021 |
(1) |
||||||||
Current assets: |
|||||||||||
Cash and cash equivalents |
$ 67,993 |
$ 25,218 |
|||||||||
Short-term investments |
599,032 |
708,737 |
|||||||||
Accounts receivable |
30,220 |
22,492 |
|||||||||
Inventory |
15,379 |
15,801 |
|||||||||
Other current assets |
20,831 |
23,333 |
|||||||||
Total current assets |
733,455 |
795,581 |
|||||||||
Long-term investments |
37,363 |
64,828 |
|||||||||
Property, plant and equipment, net |
60,980 |
60,510 |
|||||||||
Operating lease right-of-use assets |
114,296 |
117,025 |
|||||||||
Goodwill |
76,501 |
76,501 |
|||||||||
Other assets |
1,521 |
2,744 |
|||||||||
Total assets |
$ 1,024,116 |
$ 1,117,189 |
|||||||||
LIABILITIES AND STOCKHOLDERS' EQUITY |
|||||||||||
Current liabilities: |
|||||||||||
Accounts payable |
12,617 |
9,747 |
|||||||||
Accrued compensation |
22,653 |
15,735 |
|||||||||
Accrued clinical trial expenses |
33,403 |
26,809 |
|||||||||
Other accrued expenses |
17,011 |
15,468 |
|||||||||
Operating lease liabilities, current portion |
19,597 |
17,441 |
|||||||||
Total current liabilities |
105,281 |
85,200 |
|||||||||
Operating lease liabilities, less current portion |
122,638 |
125,736 |
|||||||||
Development derivative liability |
- |
27,726 |
|||||||||
Liabilities related to the sales of future royalties, net |
185,604 |
195,427 |
|||||||||
Other long-term liabilities |
2,704 |
3,592 |
|||||||||
Total liabilities |
416,227 |
437,681 |
|||||||||
Commitments and contingencies |
|||||||||||
Stockholders' equity: |
|||||||||||
Preferred stock |
- |
- |
|||||||||
Common stock |
19 |
19 |
|||||||||
Capital in excess of par value |
3,537,790 |
3,516,641 |
|||||||||
Accumulated other comprehensive loss |
(6,532) |
(4,157) |
|||||||||
Accumulated deficit |
(2,923,388) |
(2,832,995) |
|||||||||
Total stockholders' equity |
607,889 |
679,508 |
|||||||||
Total liabilities and stockholders' equity |
$ 1,024,116 |
$ 1,117,189 |
|||||||||
(1) The consolidated balance sheet at December 31, 2021 has been derived from the audited financial statements at that date but does not include all |
|||||||||||
of the information and notes required by generally accepted accounting principles in the United States for complete financial statements. |
|||||||||||
Nektar Therapeutics |
|||||||||||
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS |
|||||||||||
(In thousands, except per share information) |
|||||||||||
(Unaudited) |
|||||||||||
Three months ended March 31, |
|||||||||||
2022 |
2021 |
||||||||||
Revenue: |
|||||||||||
Product sales |
$ 5,688 |
$ 4,795 |
|||||||||
Non-cash royalty revenue related to the sales of future royalties |
17,561 |
18,798 |
|||||||||
License, collaboration and other revenue |
1,573 |
54 |
|||||||||
Total revenue |
24,822 |
23,647 |
|||||||||
Operating costs and expenses: |
|||||||||||
Cost of goods sold |
5,315 |
5,756 |
|||||||||
Research and development |
107,253 |
95,604 |
|||||||||
General and administrative |
27,339 |
31,679 |
|||||||||
Restructuring, impairment and other costs of terminated program |
1,475 |
- |
|||||||||
Total operating costs and expenses |
141,382 |
133,039 |
|||||||||
Loss from operations |
(116,560) |
(109,392) |
|||||||||
Non-operating income (expense): |
|||||||||||
Change in fair value of development derivative liability |
33,427 |
(1,599) |
|||||||||
Non-cash interest expense on liabilities related to the sales of future royalties |
(7,529) |
(13,296) |
|||||||||
Interest income and other income (expense), net |
395 |
1,412 |
|||||||||
Total non-operating expense, net |
26,293 |
(13,483) |
|||||||||
Loss before provision for income taxes |
(90,267) |
(122,875) |
|||||||||
Provision for income taxes |
126 |
92 |
|||||||||
Net loss |
$ (90,393) |
$ (122,967) |
|||||||||
Basic and diluted net loss per share |
$ (0.49) |
$ (0.68) |
|||||||||
Weighted average shares outstanding used in computing basic and diluted net loss per share |
185,848 |
181,370 |
|||||||||
Nektar Therapeutics |
|||||||||||
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS |
|||||||||||
(In thousands) |
|||||||||||
(Unaudited) |
|||||||||||
Three months ended March 31, |
|||||||||||
2022 |
2021 |
||||||||||
Cash flows from operating activities: |
|||||||||||
Net loss |
$ (90,393) |
$ (122,967) |
|||||||||
Adjustments to reconcile net loss to net cash used in operating activities: |
|||||||||||
Non-cash royalty revenue related to the sales of future royalties |
(17,561) |
(18,798) |
|||||||||
Non-cash interest expense on liabilities related to the sales of future royalties |
7,529 |
13,296 |
|||||||||
Change in fair value of development derivative liability |
(33,427) |
1,599 |
|||||||||
Non-cash research and development expense |
4,951 |
2,248 |
|||||||||
Stock-based compensation |
20,961 |
23,898 |
|||||||||
Depreciation and amortization |
3,730 |
3,543 |
|||||||||
Amortization of premiums (discounts), net and other non-cash transactions |
1,276 |
2,345 |
|||||||||
Changes in operating assets and liabilities: |
|||||||||||
Accounts receivable |
(7,728) |
9,733 |
|||||||||
Inventory |
422 |
(1,516) |
|||||||||
Operating leases, net |
1,787 |
1,541 |
|||||||||
Other assets |
2,864 |
6,183 |
|||||||||
Accounts payable |
2,998 |
779 |
|||||||||
Accrued compensation |
6,918 |
8,981 |
|||||||||
Other accrued expenses |
7,249 |
(7,950) |
|||||||||
Net cash used in operating activities |
(88,424) |
(77,085) |
|||||||||
Cash flows from investing activities: |
|||||||||||
Purchases of investments |
(93,493) |
(295,314) |
|||||||||
Maturities of investments |
227,974 |
303,612 |
|||||||||
Sales of investments |
- |
5,036 |
|||||||||
Purchases of property, plant and equipment |
(4,203) |
(2,876) |
|||||||||
Net cash provided by investing activities |
130,278 |
10,458 |
|||||||||
Cash flows from financing activities: |
|||||||||||
Proceeds from shares issued under equity compensation plans |
188 |
17,106 |
|||||||||
Cash receipts from development derivative liability |
750 |
750 |
|||||||||
Net cash provided by financing activities |
938 |
17,856 |
|||||||||
Effect of foreign exchange rates on cash and cash equivalents |
(17) |
(20) |
|||||||||
Net increase (decrease) in cash and cash equivalents |
42,775 |
(48,791) |
|||||||||
Cash and cash equivalents at beginning of period |
25,218 |
198,955 |
|||||||||
Cash and cash equivalents at end of period |
$ 67,993 |
$ 150,164 |
|||||||||
Supplemental disclosure of cash flow information: |
|||||||||||
Operating lease right-of-use asset recognized in exchange for lease liabilities |
$ - |
$ 1,057 |
|||||||||
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